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Join a Team that Lives to Improve Lives
People come to Genentech from across disciplines and across the world to solve our most challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what's possible. And a focus on doing the day-to-day work that makes great science happen.

The following opportunity exists in our South San Francisco, CA headquarters:

Senior Scientist, DMPK

The department of Drug Metabolism and Pharmacokinetics (DMPK) at Genentech is seeking an experienced Senior Scientist to support the biotransformation function working on small molecules and new modalities. The DMPK group is dedicated to enabling the discovery, development and commercialization of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion and pharmacokinetic properties of small molecule drug candidates. We accomplish this through the application of state of the art technologies and sciences of bioanalysis, drug metabolism, drug transport and pharmacokinetics. The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

Primary responsibilities include:

  • Profiling and identifying drug metabolites in in vitro and in vivo biological matrices using HPLC with radiometric detection and LC-MS/MS
  • Designing, executing and reporting biotransformation studies to support drug discovery or development and regulatory filings
  • Designing and implementing appropriate assays and strategy to support the development of small molecules, peptides and other modalities
  • Depending on the role: managing a group of scientists
  • We are seeking applicants for this position with the following qualifications:
  • PhD or non-PhD degree in chemistry, biochemistry, pharmaceutical sciences or other related disciplines with various levels of experience.  Title is based on the level of experience.
  • Considerable hands on experience in metabolite identification by LC-MS/MS and determination of biotransformation pathways of small molecules (peptides or other novel modalities is a plus)
  • Good understanding of enzyme kinetics and clearance mechanism in support of drug discovery or development programs (depending on the role). Depending on the role, experience of using radiolabels, conducting regulatory filing studies, and writing scientific reports
  • Good writing and verbal communication skills

Who We Are
Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society.  We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.

Job Information

  • Job ID: 58744463
  • Location:
    South San Francisco, California, United States
  • Position Title: Senior Scientist, DMPK
  • Company Name: Genentech
  • Job Function: DMPK Research Scientist
  • Job Type: Full-Time
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