Description
Job Description
Regeneron Pharmaceutical's Analytical and Biological Mass Spectrometry Group (ABMS), located in Tarrytown, NY, is seeking a highly motivated Sr. Scientist. In this role, you will work in an innovative mass spectrometry (MS) lab and develop LC-MS methods for characterizing biotherapeutic products to support all stages of drug development, from early-stage candidate selections to late-stage regulatory submissions. You will conduct and develop innovative technologies to support a diverse Regeneron's R&D pipeline.
A Typical Day in the Role Might Look Like:
- Design, execute, and clearly communicate analytical characterization for biotherapeutics, including adeno-associated virus (AAV), monoclonal and bispecific antibodies, Fc-fusion proteins, and other modalities, to support drug development.
Lead and execute characterization activities to evaluate and elucidate critical quality attributes such as charge variants, size variants, and post-translational modifications, with an emphasis on charge detection mass spectrometry (CDMS) and related native-MS approaches.
- Provide analytical support for cross-functional teams, including formulation development, upstream/downstream process development, and manufacturing to solve drug development challenges.
- Proactively advance LC-MS characterization of biotherapeutics by developing innovativetechniques that address evolving developmental needs and improve operational efficiency.
- Independently conduct sample preparation and LC-MS analyses in compliance with SOPs, and document experimental procedures and results in electronic laboratory notebook (ELN).
- Author and review regulatory submission documents, including IND, comparability, and BLA reports, and contribute to manuscripts for peer-reviewed publications.
- Represent analytical development on project teams, provide subject matter expertise, and communicate results at internal and external meetings.
Requirements
This Role Might Be For You If You:
- You thrive in a fast-paced, collaborative environment and consistently deliver results with efficiency and ownership.
- You quickly learn new technologies, tackle complex problems, and have a passion for science.
- You are self-motivated and proactive, prioritizing effectively, and driving work forward with minimal supervision.
To be considered for this role, you must have a BS (10+ years), MS (7+ years) or PhD degree (0-3+ years) in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a closely related field. Experience with charge detection mass spectrometry (CDMS) is strongly preferred. Experience applying LC-MS to extended characterization of AAV and monoclonal antibodies to support product and process development is a plus. Extensive experience with advanced mass spectrometers (Q Exactive Plus, Q Exactive UHMR, Q-TOF, etc.), liquid chromatography, and data processing software (Protein Metrics, Skyline, UniDec etc.) is desired. Experience with experimental design and data analysis (e.g., molecular modeling, graphing, and statistical analysis) is a plus. Please copy and paste the desired job description for this role here. If you need a copy of an existing job description please reach out to TA or work with your HR Business Partner to develop one for a new role.
